iRiS Kinetics - Label-free bimolecular binding measurements
iRiS provides a label-free multiplexed microarray platform for measuring binding interactions for a variety of biological molecules and particles including small molecules, proteins, nucleic acids, bacteria, viruses and extra-cellular vesicles. The iRiS technology allows high level of multiplexing on a low-cost, robust, compact, and easy-to-use instrument with inexpensive consumables.
iRiS Kinetics selected the small benchtop iFOUR spotter to pair with the measurement system. The iFOUR was customized to produced specific iRiS chips, printed using templates that match analysis templates on the MX-104. This makes for a very easy and seamless workflow for biologists who wish to spot their own chips in the lab.
Published research using the iFOUR
The use of the iFOUR in the iRiS workflow has also been documented in peer-reviewed research. In a 2026 study published in Scientific Reports, researchers from Boston University, iRiS Kinetics and collaborating institutions used the iFOUR as a non-contact microarray spotter to functionalize IRIS sensor chips.
Streptavidin, DNA probes and control proteins were precisely deposited onto functionalized sensor surfaces and subsequently used for label-free biomolecular interaction measurements with the multi-parametric IRIS platform.
Aslan, M., Snekvik, S., Seymour, E. et al.
Multi-parametric interferometric reflectance imaging sensor.
Scientific Reports 16, 10780 (2026)
M2 technology: iFOUR, M2-Instruments
Application: Biosensor functionalization, protein and DNA microarrays, label-free biomolecular interaction analysis
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